• Suspected and known Kawasaki disease - ESR is generally > 20 mm/hr in acugte disease, subsiding to normal 6 to 10 weeks after fever onset. An elevated ESR > 40 mm/hr in so-called incomplete Kawasaki disease is a strong indication to proceed with further laboratory testing and an echocardiogram. A marked elevation of 100 mm/hr or greater, or a persistent elevation, is consistent with active angitis and is predictive of coronary artery involvement. • Suspected bursitis - ESR is usually elevated, but the ESR does not distinguish between infection and other causes of inflammation. • Suspected giant cell (temporal) arteritis - marked elevation of ESR (e.g., > 50 mm/hr) is a hallmark finding in this arteritis. A normal ESR level combined with low clinical suspicion reduces the probability of disease to less than 1%. Normal ESR has been noted in up to 24% of biopsy-proven giant cell arteritis patients before steroid therapy.

• Suspected gout - ESR often is mildly increased during gout attacks but may be as high as 2 times normal, indicating inflammation. • Suspected Lyme disease - ESR >30 mm/hr may be seen in 25% to 50% of patients. ESR in patients with chronic arthritis ranges from 4 to 54 mm/hr (median, 24 mm/hr). In patients with cardiac involvement, the ESR ranges from 3 to 74 mm/hr (median, 47 mm/hr) ESRs ranging from 2 to 46 mm/hr (median, 22 mm/hr) • Suspected multiple myeloma - elevated ESR may raise suspicion for multiple myeloma, but it is not diagnostic for the disease.

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• Suspected pelvic inflammatory disease - elevated ESR supports the diagnosis of PID in patients with pelvic tenderness and signs of lower genital trace inflammation, in whom no other cause(s) for the illness can be identified. Patients with chlamydial PID tend to present with more highly elevated ESR (over 30 mm/hr) than those with gonococcal PID.

• Suspected rheumatoid arthritis - ESR should be included as part of the baseline laboratory evaluation. Calvin klein watches for men. An elevated ESR suggests poor prognosis.

• Suspected septic arthritis - In a series of children with septic arthritis of the hip, the average ESR was 94 mm/hr. The combination of ESR >40 mm/hr, nonweight-bearing status, and serum WBC count >12,000/mm3 helps differentiate septic arthritis from transient synovitis of the hip in children. The ESR is usually >60 mm/hr in patients over 60 years of age with septic arthritis. • Suspected subacute thyroiditis - ESR is usually markedly elevated in subacute granulomatous thyroiditis and normal in subactue lymphocytic thyroiditis. • The ESR may be elevated >100 mm/hr in painful thyroiditis.

• A normal ESR excludes the diagnosis of active subacute granulomatous thyroiditis. • In silent thyroiditis (painless) the ESR may be normal or only slightly elevated. • In patients with recurrent subacute thyroiditis the ESR may be. Clinical Application • ESR is a measurement of the rate at which the RBCs settle in saline solution or plasma over a specified time period. It is nonspecific and should not diagnostic for any particular organ disease or injury and thus is not useful as a screening test.